Structure and inflammatory activity of the LPS isolated from Acetobacter pasteurianus CIP103108

Acetobacter pasteurianus is an acetic add-producing Gram-negative bacterium commonly found associated with plants and plant products and widely used in the production of fermented foods, such as kefir and vinegar. Due to the acid conditions of the bacterium living habitat, uncommon structural features composing its cell envelope are expected. In the present work we have investigated the A. pasteurianus CIP103108 lipopolysaccharide (LPS) structure and immunoactivity. The structure of the lipid A and of two different O-polysaccharides was assessed. Furthermore, immunological studies with human cells showed a low immunostimulant activity of the isolated LPS, in addition to a slight capability to lower the NF-kappa B activation upon stimulation by toxic LPS.

Mots clés

lipopolysaccharides (LPS) Gram-negative bacteria innate immunity MD2-TLR4 Acetobacter pasteurianuss gram negative bacteria

acétobacter pasteurianus bactérie gram négatif kéfir lps activité immunostimulante

Domaines

Autre [q-bio.OT] Polymères

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2018_Pallach_International Journal of Biological Macromolecules.pdf (1.8 Mo)

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https://hal.science/hal-01956104

Soumis le : vendredi 14 décembre 2018-20:06:52

Dernière modification le : mercredi 17 avril 2024-09:36:15

Archivage à long terme le : vendredi 15 mars 2019-16:54:45

Dates et versions

hal-01956104 , version 1 (14-12-2018)

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Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

HAL Id : hal-01956104 , version 1
DOI : 10.1016/j.ijbiomac.2018.08.035
PRODINRA : 455867
PUBMED : 30098357
WOS : 000447682100114

Citer

Mateusz Pallach, Flaviana Di Lorenzo, Fabio Alessandro Facchini, Djamel Gully, Eric Giraud, et al.. Structure and inflammatory activity of the LPS isolated from Acetobacter pasteurianus CIP103108. International Journal of Biological Macromolecules, 2018, 119, pp.1027-1035. ⟨10.1016/j.ijbiomac.2018.08.035⟩. ⟨hal-01956104⟩

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